In you web.config file, make sure you have the following key under the <modules> section.
<system.webServer>
...
<modules>
...
<add name="EkUrlAliasModule" type="UrlAliasingModule" preCondition="integratedMode" />
...
</modules>
...
</system.webServer>
You may ensure that your web.config contains all of the handler mappings from the IIS 7 example configuration file (Usually found in C:\Program Files\Ektron\CMS400vXX\CommonFiles\IIS7Web.config).